Skip to main content

The Use Of A Leucine Ester To Improve Exercise Performance And Muscle Anabolism

ID: 2018-008 Using beta hydroxybutyrate (bHB) and an ester of the amino acid leucine to provide a ready source of energy during exercise and promote muscle protein synthesis.

Principal Investigator: Benjamin Bikman

Most exercise drinks provide a source of glucose. However, as an increasing number of people are adopting a low-carbohydrate diet, there is an increasing need for a non-glucose source of fuel. Also within the realm of the low-carbohydrate lifestyle, some are concerned with the lack of nutrients to support muscle growth. The combination of bHB and leucine addresses both of these concerns: providing a non-glucose fuel and a building block for muscle protein synthesis.

The structure of the molecule consists in: the carboxylic acid of leucine is esterified either with bHB or with the primary or secondary alcohol of butane-1,3-diol. The synthesis of the ester of leucine ensures that the consumption of the leucine ester as a source of energy and for muscle building is not accompanied by excess amounts of sodium. The molecule is ingested as an ester. Upon digestion, the ester bond is broken, providing bHB, which is converted into acetyl-coa for energy production, and leucine, providing amino acid for muscle protein synthesis.

About the Market:
The invention has the potential to be used a supplement for people adhering to a low-carbohydrate diet.

For more information, contact Mike Alder (801-422-3049)

Links and Resources

  1. One Page Summary PDF
  2. Inventor Webpage - Benjamin Bikman
  3. Bikman Lab Webpage