Tonic Cycles Decellularization Method for Solid Organs ID: 2013-070
A novel method for decellularizing solid organs to improve organ transplant compatibility by preserving the extracellular matrix.
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Technology Overview
This technology involves a unique process of alternating washes with hypertonic saline, deionized water, and sodium dodecyl sulfate (SDS) for decellularizing solid organs such as kidneys, hearts, and lungs. The method aims to minimize exposure to damaging chemicals while preserving the extracellular matrix (ECM), enabling the ECM to be repopulated with the recipient's cells, thereby improving transplant compatibility.
Key Advantages
- Reduced exposure time to damaging chemicals like SDS
- Preservation of the extracellular matrix, enhancing organ transplant success
- Improved DNA extraction, reducing the risk of transplant rejection
- Potential for increased compatibility and longevity of transplanted organs
Problems Addressed
- Limitations of existing decellularization methods that can damage the ECM
- High risk of transplant rejection due to presence of antigens in donor organs
- Challenges in removing cellular material without compromising organ structure
Market Applications
- Organ transplantation procedures, particularly for kidneys, hearts, and lungs
- Biomedical research, specifically in tissue engineering and regenerative medicine
- Pharmaceutical testing, allowing for more accurate in vitro organ models
Additional Information
Technology ID: 2013-070
Sell Sheet: Download the Sell Sheet here
Market Analysis: Contact us for a more in-depth market report
Date Published: 13 May, 2025
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