TALENs-Based Biotechnological Invention for HIV-1 Inactivation ID: 2015-078
A groundbreaking biotechnological invention utilizing TALENs to specifically target and inactivate HIV-1 by editing its DNA sequence.
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Technology Overview
This technology involves the development and application of Transcription Activator-Like Effector Nucleases (TALENs) to cut specific DNA sequences, particularly targeting the HIV-1 long terminal repeat (LTR) regions. The main objective is to produce HIV-1-resistant cells, utilizing a humanized mouse model as a preliminary test platform. This approach aims to maintain immune system integrity and halt the progression of AIDS in humans.
Key Advantages
- Specific targeting of HIV-1 DNA sequences, minimizing off-target effects
- Potential to produce HIV-1-resistant cells, offering a long-term therapeutic solution
- Utilizes a humanized mouse model for preliminary testing, facilitating the transition to human applications
- Focuses on targeting stem cell populations, offering a more sustainable solution compared to treatments focusing on mature T cells
Problems Addressed
- Inactivation of HIV-1 to prevent the progression of AIDS
- Overcomes limitations of temporary treatments by targeting the genetic source of HIV-1
- Provides a potential long-term solution to HIV-1 by altering the host's DNA to resist the virus
Market Applications
- Therapeutic interventions for HIV-1 and AIDS
- Development of HIV-resistant cell therapies
- Potential for broader applications in gene editing for other viral infections
Additional Information
Technology ID: 2015-078
Sell Sheet: Download the Sell Sheet here
Market Analysis: Contact us for a more in-depth market report
Date Published: 28 March, 2025
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