Stereospecific Synthesis of Aziridines ID: 2014-001

An innovative method for synthesizing unprotected N-H and N-Me aziridines directly from olefins.

Technology Overview

This technology, developed by researchers including Daniel Halsell Ess at Brigham Young University, presents a novel approach to the direct stereospecific synthesis of unprotected N-H and N-Me aziridines from olefins. Utilizing 0-(2,4-dinitrophenyl)hydroxylamine (DPH) and rhodium catalysis, this method is operationally simple, scalable, and efficient, functioning well at ambient temperatures without the need for external oxidants. The process yields good-to-excellent results and is supported by experimental data and quantum-mechanical calculations.

Key Advantages

• Operationally simple and scalable approach
• Efficient synthesis at ambient temperature
• No need for external oxidants
• Good-to-excellent yields
• Potential for synthesizing bioactive compounds

Problems Addressed

• Complexity and inefficiency in traditional aziridine synthesis methods
• Requirement for external oxidants in conventional processes
• Difficulty in achieving stereospecific synthesis

Market Applications

• Synthesis of pharmaceuticals and bioactive compounds
• Development of new synthetic pathways in organic chemistry
• Manufacture of agrochemicals

Additional Information

Technology ID: 2014-001
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Date Published: 06 May, 2025