Phosphinoamide-Scaffolded Heterobimetallic Palladium-Titanium Catalysts for Allylic Amination ID: 2015-040

This technology introduces a novel catalyst system for efficient allylic amination at room temperature, revolutionizing organic synthesis.

Technology Overview

The document details the development of phosphinoamide-scaffolded heterobimetallic palladium-titanium complexes as catalysts, which enable the allylation of allylic chlorides with secondary amine nucleophiles under mild conditions. This groundbreaking approach overcomes the limitations of traditional monometallic catalysts, facilitating reactions that were previously challenging or inefficient.

Key Advantages

• Enables allylic amination at room temperature
• Efficiently catalyzes reactions with sterically hindered secondary amines
• Outperforms traditional palladium catalyst systems in effectiveness
• Facilitates intramolecular cyclization, yielding valuable pharmaceutical intermediates

Problems Addressed

• Difficulty in allylating allylic chlorides with sterically hindered secondary amines
• Limitations of monometallic catalysts in achieving efficient catalysis at room temperature
• Challenges in forming C-N bonds under mild conditions
• Inefficiency in synthesizing complex pharmaceutical compounds through intramolecular cyclization

Market Applications

• Pharmaceutical synthesis, particularly in designing complex molecules
• Organic synthesis, offering new pathways and methodologies
• Development of advanced catalyst systems for industrial chemical processes
• Academic research, furthering the understanding of bimetallic catalysis

Additional Information

Technology ID: 2015-040
Sell Sheet: Download the Sell Sheet here
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Date Published: 28 March, 2025