Novel Microfluidic Device for Nucleic Acids Quantitation ID: 2014-072

A breakthrough microfluidic device enabling label-free, detectorless quantitation of nucleic acids, revolutionizing disease biomarker detection.

Technology Overview

This innovative technology comprises a microfluidic device that quantifies unamplified nucleic acids through flow distance measurement in microchannels. Developed at Brigham Young University with NIH funding, it leverages poly(dimethylsiloxane) microchannels with nucleic acid receptors for sensitive detection of DNA analogues of microRNAs, crucial biomarkers in diseases like cancer and kidney disease. Its unique approach allows for the detection of single-base mismatches and operates effectively in complex fluids such as synthetic urine, showcasing its potential for direct, point-of-care medical diagnostics.

Key Advantages

• Label-free and detectorless quantitation, simplifying the detection process
• Ability to detect single-base mismatches, enhancing diagnostic accuracy
• No need for nucleic acid amplification, reducing costs and complexity
• Effective in complex sample matrices like synthetic urine, broadening application scope
• Significant potential for point-of-care diagnostic applications, improving patient outcomes

Problems Addressed

• Complexity and high costs associated with current nucleic acid detection methods
• Limited sensitivity and specificity in existing diagnostic devices
• Need for amplification in traditional nucleic acid quantitation techniques
• Challenges in detecting biomarkers in non-invasive samples for early disease detection

Market Applications

• Point-of-care diagnostic devices for early detection of diseases like cancer and kidney disease
• Non-invasive testing platforms for disease monitoring and management
• Research tools for studying micro
• RNAs and other nucleic acid biomarkers
• Development of cost-effective, portable diagnostic devices for low-resource settings

Additional Information

Technology ID: 2014-072
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Date Published: 07 May, 2025