Novel Method for Producing Therapeutic Proteins Using Chicken Primordial Germ Cells ID: 2024-055
A groundbreaking approach to biologically produce therapeutic proteins in chicken egg whites through genetically engineered chickens.
Photo by starlineart - stock.adobe.com
Technology Overview
This technology introduces a novel method for the production of therapeutic proteins by engineering chicken primordial germ cells (cPGCs) to express therapeutic proteins in the egg whites of chickens. By inserting genes encoding these proteins at the ovalbumin locus, the technology ensures the proteins are produced in high quantities in the egg whites, leveraging a rapid, selectable cassette exchange system for efficient gene insertion.
Key Advantages
- Surpasses traditional CRISPR/Cas9 methods by eliminating positional effects and increasing efficiency
- Utilizes a Cre-recombinase system with hetero-specific lox sites for precise and efficient gene insertion
- Enables the production of therapeutic proteins in a cost-effective and scalable manner
Problems Addressed
- Reduces the cost and complexity of producing therapeutic proteins
- Overcomes inefficiencies and limitations associated with traditional gene editing and protein production methods
- Provides a scalable solution for the production of biologically derived therapeutic proteins
Market Applications
- Biologics production leveraging transgenic animals
- Development of biosimilars and novel biopharmaceuticals
- Partnerships with biotechnology and pharmaceutical companies for cost-effective protein production
Additional Information
Technology ID: 2024-055
Sell Sheet: Download the Sell Sheet here
Market Analysis: Contact us for a more in-depth market report
Date Published: 07 May, 2025
Connect with the Tech Transfer to:
- Meet with the technology manager
- Receive additional information
- Request a marketing plan report