Natural Biflavanoid Compounds as Tryptase Inhibitors ID: 2018-059

This technology introduces a groundbreaking approach to inhibiting tryptase activity using natural biflavanoid compounds, offering a novel pathway for treating inflammatory conditions.

Technology Overview

The technology encompasses the discovery and development of natural biflavanoid compounds, specifically amentoflavone and its analogs, as potent inhibitors of tryptase. Tryptase, a serine protease released from mast cells, is implicated in various inflammatory responses and conditions. These natural compounds have been identified through agnostic screening and have shown significant promise in biochemical assays for their inhibitory activity against tryptase, positioning them as potential therapeutic agents.

Key Advantages

• Utilizes natural compounds, potentially ensuring a safer profile and rapid approval for therapeutic use
• Offers a novel treatment pathway for inflammatory conditions and allergic reactions
• May bypass extensive clinical trials required for synthetic drugs, accelerating the path to market
• Leverages historical use in traditional medicines, supporting efficacy and safety

Problems Addressed

• Inappropriate mast cell activation leading to allergic reactions and mastocytosis
• Limited availability of safe and effective tryptase inhibitors for therapeutic use
• The need for rapid development and approval of new therapeutic agents

Market Applications

• Development of novel anti-inflammatory drugs
• Therapeutic agents for treating allergic reactions
• Integration into existing treatment regimens for mastocytosis and related conditions

Additional Information

Technology ID: 2018-059
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Date Published: 28 March, 2025