Isotope Mass Defect Measurement for Biochemical Synthesis and Degradation ID: 2015-006

An innovative method for in vivo measurement of biochemical synthesis and degradation using isotope mass defect.

Technology Overview

This technology introduces a novel approach for measuring biochemical synthesis and degradation in vivo by focusing on the changes in the spacing within isotopic distributions, termed the isotope mass defect. Unlike traditional methods that measure isotopic label abundance using mass spectrometry, this invention provides a new metric reflecting isotope incorporation into molecules, such as proteins, with potential broad applications in research and drug development.

Key Advantages

• Enables the use of various types of mass spectrometers, including time-of-flight, Fourier transform, and orbitrap
• Increases statistical confidence in results by combining traditional isotope abundance data with mass defect measurements
• Offers enhanced instrument compatibility and measurement confidence over existing techniques
• Facilitates broader applications in measuring protein turnover and molecular fluxes

Problems Addressed

• Overcomes limitations in the applicability of previous methods to different mass spectrometry instruments
• Improves accuracy and confidence in measuring biochemical synthesis and degradation
• Addresses the need for a more versatile tool in studying drug effects or disease etiologies at the molecular level

Market Applications

• Pharmaceutical research and development, particularly in drug discovery and efficacy testing
• Academic research in biochemistry, molecular biology, and related fields
• Biotechnology companies focusing on protein synthesis and degradation
• Healthcare diagnostics involving molecular biomarkers

Additional Information

Technology ID: 2015-006
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Date Published: 28 March, 2025