Fungal Production of Cyclopamine ID: 2012-074
An innovative method to produce cyclopamine using a specific fungus, enhancing efficiency and scalability in pharmaceutical applications.
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Technology Overview
This technology identifies, isolates, and cultivates a particular fungus capable of producing cyclopamine and its glycosylated forms. Cyclopamine is a critical compound used to inhibit the hedgehog signaling pathway, offering therapeutic potential in treating cancers such as medulloblastoma and basal cell carcinoma. Traditionally sourced from the plant Veratrum californicum, which is challenging to grow, this fungal production method promises a more viable and scalable alternative for cyclopamine production.
Key Advantages
- Enhanced efficiency and scalability in cyclopamine production
- Reduces reliance on difficult-to-cultivate plants as the primary source
- Opens up new avenues for pharmaceutical applications and research
- Exclusive method with no known prior publications, patents, or disclosures
Problems Addressed
- Difficulty in sourcing cyclopamine due to cultivation challenges of its traditional plant source
- Limited scalability and efficiency in existing cyclopamine production methods
Market Applications
- Pharmaceuticals for the treatment of hedgehog pathway-related cancers, such as medulloblastoma and basal cell carcinoma
- Research and development in cancer therapeutics
- Potential licensing opportunities for pharmaceutical companies, with initial interest from Infinity Pharmaceuticals Inc
Additional Information
Technology ID: 2012-074
Sell Sheet: Download the Sell Sheet here
Market Analysis: Contact us for a more in-depth market report
Date Published: 30 June, 2025
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