Extending Lifespan through Bacterial Methionine Metabolism ID: 2017-026
This research identifies how altering bacterial genes related to methionine metabolism can extend or decrease the lifespan of Drosophila melanogaster.
Photo by Andrey Bandurenko - stock.adobe.
Technology Overview
The study explores the impact of bacterial methionine and cysteine metabolism on the lifespan of fruit flies, using a meta-genome wide association approach to pinpoint which bacterial genes influence lifespan. By testing on Escherichia coli mutants, the research highlights the critical role of the transulfuration pathway and the potential of gut microbiota manipulation to mimic dietary restriction benefits.
Key Advantages
- Offers a novel approach to extending lifespan through gut microbiota manipulation
- Highlights the importance of sulfur-containing amino acids in lifespan regulation
- Employs a meta-genome wide association approach for precise identification of influential bacterial genes
- Builds on the concept of dietary restrictions for lifespan extension, providing a non-dietary intervention strategy
Problems Addressed
- Challenges in identifying non-genetic, reversible methods for lifespan extension
- Lack of understanding of the specific bacterial genes that influence host lifespan
- Need for alternative strategies to mimic the lifespan-extending effects of dietary restrictions
Market Applications
- Development of probiotic supplements aimed at lifespan extension
- Research tools for studying the impact of gut microbiota on aging
- Therapeutic interventions targeting aging and age-related diseases
Additional Information
Technology ID: 2017-026
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Date Published: 28 March, 2025
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