Cyclooxygenase-3 (COX-3) Proteins: Expression, Function, and Therapeutic Potential ID: 2013-065

This research unveils the intricate expression and multifaceted roles of COX-3 proteins in rats and humans, offering new therapeutic avenues.

Technology Overview

The study meticulously explores the expression and function of cyclooxygenase-3 (COX-3) proteins, revealing their production through complex recoding mechanisms such as ribosomal frameshifting and alternative translational initiation. It highlights the tissue-specific expression of COX-3 mRNA, the generation of multiple proteins with enzymatic activities akin to COX-1, and their significant roles in physiological and pathological processes.

Key Advantages

• Unveils tissue-specific expression and production of multiple COX-3 proteins
• Identifies novel recoding mechanisms for COX-3 m
• RNA translation
• Expands understanding of COX-3 proteins' roles as cytosolic enzymes and nuclear factors
• Highlights potential of COX-3 proteins as targets for NSAIDs
• Provides foundational knowledge for therapeutic applications targeting COX-3 proteins

Problems Addressed

• Addresses the complexity of COX-3 protein expression and function
• Overcomes challenges in studying the translation mechanisms of COX-3 m
• RNA
• Identifies potential therapeutic targets within COX-3 protein variants for drug development

Market Applications

• Development of novel NSAIDs targeting COX-3 proteins for enhanced pain relief and anti-inflammatory effects
• Therapeutic applications in treating diseases with a prostaglandin synthesis component
• Use in pharmaceutical research and development for creating more effective and targeted drugs

Additional Information

Technology ID: 2013-065
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Date Published: 13 May, 2025