Conditional Overexpression of RAGE in Murine Lungs and Its Implications for COPD ID: 2013-044

This study demonstrates how conditional overexpression of RAGE in the lungs can mimic COPD-like symptoms, offering new insights into the disease's pathogenesis.

Technology Overview

The research conducted at Brigham Young University focuses on the effects of conditional overexpression of the receptor for advanced glycation end-products (RAGE) in adult murine lungs. By creating a model that simulates chronic obstructive pulmonary disease (COPD) through RAGE overexpression, the study provides a detailed examination of the resultant lung remodeling, inflammation, and potential pathways for therapeutic intervention.

Key Advantages

• Provides a novel model for studying COPD without the need for tobacco smoke exposure
• Highlights the critical role of RAGE signaling in lung tissue remodeling and inflammation
• Offers potential targets for therapeutic intervention in COPD treatment

Problems Addressed

• Lack of animal models that accurately simulate COPD pathogenesis without external stressors like tobacco smoke
• Insufficient understanding of the molecular mechanisms driving COPD progression
• Need for new therapeutic targets to treat or manage COPD

Market Applications

• Pharmaceutical development targeting RAGE pathways for COPD treatment
• Diagnostic tools based on RAGE expression levels in lung tissue
• Preclinical research models for studying lung diseases and potential interventions

Additional Information

Technology ID: 2013-044
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Date Published: 13 May, 2025