Chimeric Claudin Proteins for Modulating Tight Junctions ID: 2019-026
This technology introduces synthetic chimeric claudin proteins designed to transiently modulate tight junctions in epithelial and endothelial cells for therapeutic and biotechnological applications.
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Technology Overview
The development focuses on the creation of chimeric claudin (CLDN) proteins to control the paracellular pathway between cells by modulating tight junctions (TJs). These proteins are engineered through modifications of claudins, incorporating elements such as human ApoA IV to influence cell-cell interactions, enhance tissue engineering, and support drug delivery mechanisms. Experiments, including those on zebrafish embryos, have demonstrated the potential of these chimeras to alter cell interactions and muscle structure, indicating their effectiveness in modifying biological barriers.
Key Advantages
- Enables transient modulation of tight junctions for controlled permeability
- Supports advanced drug delivery and therapeutic interventions
- Promotes tissue engineering and cell proliferation through enhanced mechanotransduction
- Offers potential solutions for diseases like preeclampsia and challenges like drug delivery across the blood-brain barrier
Problems Addressed
- Lack of translational solutions for transiently modulating tight junctions
- Challenges in drug delivery due to impermeable biological barriers
- Difficulties in tissue engineering and cell proliferation
- Limitations in treating conditions such as preeclampsia and enhancing organogenesis
Market Applications
- Pharmaceuticals: Enhancing drug delivery mechanisms
- Medical Therapeutics: Wound healing and treatment of conditions like preeclampsia
- Tissue Engineering: Improving mechanotransduction and cell proliferation
- Cosmetics and Skin Treatments: Application in beauty products and skin health
Additional Information
Technology ID: 2019-026
Sell Sheet: Download the Sell Sheet here
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Date Published: 28 March, 2025
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