BRDGR: Bridge RNA Recombinase Targeted Nucleotide Enrichment and Sequencing Prep ID: 2024-058
A revolutionary method for preparing targeted DNA locations for sequencing, preserving native modifications and enabling direct sequencing.
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Technology Overview
BRDGR utilizes bridge RNAs to specifically enrich targeted DNA sequences for sequencing without denaturing the DNA, eliminating the need for PCR amplification. This technology allows for the direct sequencing of DNA, maintaining its double-stranded nature and enabling duplexed reads with Oxford Nanopore technologies.
Key Advantages
- Preserves the native modifications of DNA
- Eliminates the need for PCR amplification, reducing complexity and potential errors
- Enables direct sequencing with Oxford Nanopore technologies
- Maintains the double-stranded nature of DNA, allowing for duplexed reads
Problems Addressed
- Complexity and errors introduced by PCR amplification
- Loss of native DNA modifications during preparation for sequencing
- Inability to maintain double-stranded DNA integrity in sequencing preparations
Market Applications
- Targeted genetic sequencing for research and diagnostics
- Genomic modifications and editing research
- Potential use in personalized medicine and genetic disease diagnosis
- Commercial licensing opportunities for biotechnology firms
Additional Information
Technology ID: 2024-058
Sell Sheet: Download the Sell Sheet here
Market Analysis: Contact us for a more in-depth market report
Date Published: 28 March, 2025
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