Biofluid-Based Assay for Predicting Drug Binding ID: 2024-049

A revolutionary assay that predicts drug binding on a proteomic scale with residue-specific resolution, enhancing drug discovery processes.

Technology Overview

This technology introduces a novel biofluid-based assay designed to predict drug binding on a proteomic scale, offering residue-specific resolution without the need for protein purification. Utilizing protein folding stability, it detects drug-protein interactions by measuring changes in protein stability due to drug binding. This method is rooted in the groundbreaking work of H.J.L. Lin and colleagues, which quantified the structural stabilities of human blood plasma proteins.

Key Advantages

• Enables the assessment of drug binding in complex biological mixtures
• Provides residue-specific information on drug-protein interactions
• Eliminates the need for protein purification, streamlining the drug discovery process
• Offers a novel approach to understanding amyloid-driven pathologies

Problems Addressed

• Difficulty in assessing drug binding in complex mixtures due to the requirement of protein purification
• Lack of residue-specific information on drug-protein interactions
• Challenges in early diagnosis and prevention of amyloid-driven diseases like transthyretin-mediated amyloidosis

Additional Information

Technology ID: 2024-049
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Date Published: 28 March, 2025