Advancements in Mass Spectrometry for Enhanced Proteome Analysis ID: 2021-051

This technology revolutionizes proteome analysis through improved mass spectrometry techniques, particularly for single-cell and low-input samples.

Technology Overview

The discussed technology focuses on enhancing mass spectrometry (MS) methods to improve the quality and coverage of proteome analysis. It introduces a novel approach by accumulating multiple ions simultaneously for extended periods before multiplexed fragmentation and analysis. This method, especially beneficial for single-cell and low-input samples, aims to produce more complete MS/MS spectra without compromising the number of precursors analyzed. The use of high-resolution Orbitrap Tribrid systems and strategies for augmenting precursor prioritization are key components of this advancement.

Key Advantages

• Enhanced quality and coverage of proteome analysis in single-cell and low-input samples
• Increased confidence in peptide identification through more complete MS/MS spectra
• Efficient utilization of high-resolution data acquisition technologies
• Improved precursor prioritization, maximizing protein discovery

Problems Addressed

• Low coverage and quality of proteome analysis in samples with limited material
• Insufficient peptide identification due to incomplete MS/MS spectra
• Inefficient precursor selection and prioritization in mass spectrometry

Market Applications

• Biomedical research focusing on single-cell analysis and proteomics
• Pharmaceutical industry for drug discovery and biomarker identification
• Academic and clinical laboratories specializing in proteome research
• Development of analytical instruments and software for mass spectrometry

Additional Information

Technology ID: 2022-002
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Date Published: 28 March, 2025