2-(Pyrazolo[1,5-a]pyrimidin-3-yl)benzothiazoles as Fluorescent Reporter Molecules ID: 2021-039

A novel class of fluorescent reporter molecules for enhancing drug discovery assays targeting specific enzymes.

Technology Overview

This technology introduces a new class of compounds, 2-(Pyrazolo[1,5-a]pyrimidin-3-yl)benzothiazoles, designed as fluorescent reporter molecules. These molecules are engineered for assays that identify inhibitors of the JAK1 JH2 Pseudokinase and VPS34 enzymes. Featuring a unique benzothiazole and pyrazolo[1,5-a]pyrimidine molecular structure, these compounds exhibit fluorescence changes upon binding, serving as innovative tools in drug discovery and assay development.

Key Advantages

• Novel molecular structure enabling precise enzyme targeting
• Fluorescent properties that vary with environmental polarity, allowing for sensitive detection of binding events
• Potential to significantly enhance the efficiency and accuracy of drug discovery assays
• Offers a method to identify compounds with high binding affinities for targeted enzymes

Problems Addressed

• Difficulty in identifying inhibitors with high specificity and affinity for JAK1 JH2 Pseudokinase and VPS34
• Lack of sensitive and specific reporter molecules in assay development for drug discovery

Market Applications

• Drug discovery and development for diseases involving JAK1 JH2 Pseudokinase and VPS34 pathways
• Development of high-throughput screening assays for pharmaceutical research
• Academic research focusing on enzyme inhibition and molecular interaction studies

Additional Information

Technology ID: 2022-002
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Date Published: 28 March, 2025